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Pilot’s Handbook of Aeronautical Knowledge

FAA-H-8083-25C Version October 20, 2025

Chapter 17

Aeromedical Factors

Adverse affects of various drugs.
Figure 17-9. Adverse affects of various drugs.

Some drugs that are classified as neither stimulants nor depressants have adverse effects on flying. For example, some antibiotics can produce dangerous side effects, such as balance disorders, hearing loss, nausea, and vomiting. While many antibiotics are safe for use while flying, the infection requiring the antibiotic may prohibit flying. In addition, unless specifically prescribed by a physician, do not take more than one drug at a time, and never mix drugs with alcohol because the effects are often unpredictable.

The dangers of illegal drugs also are well documented. Certain illegal drugs can have hallucinatory effects that occur days or weeks after the drug is taken. Obviously, these drugs have no place in the aviation community.

14 CFR prohibits pilots from performing crewmember duties while using any medication that affects the body in any way contrary to safety. The safest rule is not to fly as a crewmember while taking any medication, unless approved to do so by the FAA. If there is any doubt regarding the effects of any medication, consult an AME before flying.

Prior to each and every flight, all pilots must do a proper physical self-assessment to ensure safety. A great mnemonic, covered in Chapter 2 on Aeronautical Decision-Making, is IMSAFE, which stands for Illness, Medication, Stress, Alcohol, Fatigue, and Emotion.

For the medication component of IMSAFE, pilots need to ask themselves, “Am I taking any medicines that might affect my judgment or make me drowsy? For any new medication, OTC or prescribed, you should wait at least 48 hours after the first dose before flying to determine you do not have any adverse side effects that would make it unsafe to operate an aircraft. In addition to medication questions, pilots should also consider the following -

  • Do not take any unnecessary or elective medications;
  • Make sure you eat regular balanced meals;
  • Bring a snack for both you and your passengers for the flight;
  • Maintain good hydration - bring plenty of water;
  • Ensure adequate sleep the night prior to the flight; and
  • Stay physically fit.

Additionally, you should wait at least five maximal dosing intervals, the time between recommended or prescribed dosing, (e.g., a dosing interval of 5 to 6 hours would require you to wait 30 hours) before flying after taking any medication that has potentially adverse side effects (e.g., sedating or dizziness). Observing the recommended dosing interval doesn’t eliminate the risk for adverse side effects because everyone metabolizes medications differently. However, five times the dosing interval is a reasonable rule of thumb.

Altitude-Induced Decompression Sickness (DCS)

Decompression sickness (DCS) describes a condition characterized by a variety of symptoms resulting from exposure to low barometric pressures that cause inert gases (mainly nitrogen), normally dissolved in body fluids and tissues, to come out of physical solution and form bubbles. Nitrogen is an inert gas normally stored throughout the human body (tissues and fluids) in physical solution. When the body is exposed to decreased barometric pressures (as in flying an unpressurized aircraft to altitude or during a rapid decompression), the nitrogen dissolved in the body comes out of solution. If the nitrogen is forced to leave the solution too rapidly, bubbles form in different areas of the body causing a variety of signs and symptoms. The most common symptom is joint pain, which is known as “the bends.” [Figure 17-10]

What to do when altitude-induced DCS occurs:

  • Put on oxygen mask immediately and switch the regulator to 100 percent oxygen.
  • Begin an emergency descent and land as soon as possible. Even if the symptoms disappear during descent, land and seek medical evaluation while continuing to breathe oxygen.
  • If one of the symptoms is joint pain, keep the affected area still; do not try to work pain out by moving the joint around.
  • Upon landing, seek medical assistance from an FAA medical officer, AME, military flight surgeon, or a hyperbaric medicine specialist. Be aware that a physician not specialized in aviation or hypobaric medicine may not be familiar with this type of medical problem.
  • Definitive medical treatment may involve the use of a hyperbaric chamber operated by specially-trained personnel.
  • Delayed signs and symptoms of altitude-induced DCS can occur after return to ground level regardless of presence during flight.

DCS After Scuba Diving

Scuba diving subjects the body to increased pressure, which allows more nitrogen to dissolve in body tissues and fluids. [Figure 17-11] The reduction of atmospheric pressure that accompanies flying can produce physical problems for scuba divers. A pilot or passenger who intends to fly after scuba diving should allow the body sufficient time to rid itself of excess nitrogen absorbed during diving. If not, DCS due to

Signs and symptoms of altitude decompression sickness.
Figure 17-10. Signs and symptoms of altitude decompression sickness.

evolved gas can occur during exposure to low altitude and create a serious inflight emergency.

The recommended waiting time before going to flight altitudes of up to 8,000 feet is at least 12 hours after diving that does not require controlled ascent (nondecompression stop diving), and at least 24 hours after diving that does require controlled ascent (decompression stop diving). The waiting time before going to flight altitudes above 8,000 feet should be at least 24 hours after any scuba dive. These recommended altitudes are actual flight altitudes above mean sea level (MSL) and not pressurized cabin altitudes. This takes into consideration the risk of decompression of the aircraft during flight.

Vision in Flight

Of all the senses, vision is the most important for safe flight. Most of the things perceived while flying are visual or heavily supplemented by vision. As remarkable and vital as it is, vision is subject to limitations, such as illusions and blind spots. The more a pilot understands about the eyes and how they function, the easier it is to use vision effectively and compensate for potential problems.

The eye functions much like a camera. Its structure includes an aperture, a lens, a mechanism for focusing, and a surface for registering images. Light enters through the cornea at the front of the eyeball, travels through the lens, and falls on the retina. The retina contains light sensitive cells that convert